Milan

Milan needs 2 days: the Duomo and the Galleria Vittorio Emanuele II on one, and the fashionable Brera district next to Sforza Castle on the other. April-June avoids humid summer heat and the cloudy cold of the Lombard winter. It's expensive, the Italian city with the highest cost of living after Venice, reflecting its status as the country's financial and fashion capital. It's one of the world's four fashion capitals (alongside Paris, New York and London), and Leonardo da Vinci's Last Supper, painted in a refectory, requires booking weeks ahead due to the limited daily visitor count.